Since the late 1980s, the production of Chilean Austral zone fisheries has declined by more than 70%. Recently, a joint research project between CSIRO and Chile has been developed with the aim of establishing a ‘Science-based Management Strategy for Rebuilding Chilean Fisheries’, including long-term sustainability and capacity-building for the demersal Austral zone fishery. To promote the collaboration, a recent workshop in Chile led by CSIRO scientists provided training and background on Management Strategy Evaluation (MSE) to Chilean scientists. MSE is a simulation-based method used to test the robustness of alternative fishery management strategies. Two case studies using MSE based on Patagonian grenadier and Southern hake were used to examine the consequences of different model structures on stock assessment outcomes. These model structures underpin the harvest strategy used to set the annual total allowable catch. This talk will provide background to Chilean fisheries, example applications of MSE for Chilean stocks and an overview of the Australia-Chile collaboration.